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Celldex's CDX-622 shows positive Phase 1 results, depleting mast cells and inhibiting inflammation pathways safely.

Market News
14 Jun 2026
GlobeNewsWire
View Source
Bullish
pluang ai news

Celldex Therapeutics announced positive Phase 1 trial results for CDX-622, a novel bispecific antibody targeting soluble stem cell factor (SCF) and thymic stromal lymphopoietin (TSLP). The drug showed rapid, dose-dependent reductions in serum tryptase, indicating effective mast cell depletion, and was well-tolerated with no serious adverse effects. This dual-action approach may offer new treatment options for inflammatory and allergic diseases. Celldex plans further studies in asthma, allergic rhinitis, and food allergy to explore CDX-622's therapeutic potential.

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