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BBOT's BBO-10203 disrupts RAS:PI3Kα interaction, inhibiting tumor growth without hyperglycemia

Market News
21 Apr 2026
GlobeNewsWire
View Source
Bullish
pluang ai news

BridgeBio Oncology Therapeutics (BBOT) presented preclinical data for BBO-10203, a novel small molecule that disrupts the RAS:PI3Kα interaction to inhibit cancer signaling pathways in HER2-amplified tumors without causing hyperglycemia. This drug shows strong tumor regression and effective combination with HER2 inhibitors like tucatinib and trastuzumab in models. BBO-10203 works independently of RAS or PI3Kα mutations, potentially broadening its patient application. Updated clinical trial data are expected in the second half of 2026.

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Sodexo wins major global catering contract with Meta for 130+ sites in 30+ countries

Sodexo wins major global catering contract with Meta for 130+ sites in 30+ countries

Sodexo has secured a major global contract to provide catering services across more than 130 Meta sites in over 30 countries. This large-scale partnership includes diverse locations such as headquarters, campuses, data centers, and conference centers...

Market News
Bullish
2 hours ago
Ethereum breaks $1,900 resistance, fueled by strong buying and short liquidations

Ethereum breaks $1,900 resistance, fueled by strong buying and short liquidations

Ethereum (ETH) surged past the $1,894.89 resistance level, accelerating its recovery toward the $1,940–$1,950 zone after days of consolidation. This breakout was supported by lower-than-expected U.S. inflation data, which boosted risk appetite and bu...

Technical Signals
Bullish
4 hours ago
Borralha Project drilling confirms high-grade tungsten zones, advancing development and exploration in Portugal.

Borralha Project drilling confirms high-grade tungsten zones, advancing development and exploration in Portugal.

Allied Critical Metals announced positive assay results from its 2026 drilling campaign at the Santa Helena Breccia, part of the Borralha Tungsten Project in Portugal. The first drill hole confirmed broad zones of high-grade tungsten mineralization, ...

Market News
Bullish
4 hours ago
Ethereum surges 11% in a week, driven by strong ETF inflows and Robinhood Chain activity.

Ethereum surges 11% in a week, driven by strong ETF inflows and Robinhood Chain activity.

Ethereum's price rose about 11% over the past week to around $1,920, outperforming major cryptocurrencies like Bitcoin and Solana. This rally is fueled by $96 million inflows into U.S. spot Ether ETFs early in the week, with BlackRock's ETHA product ...

Market News
Bullish
4 hours ago
XRP Ledger hits 8M activated accounts despite drop in daily active users

XRP Ledger hits 8M activated accounts despite drop in daily active users

The XRP Ledger has surpassed 8 million activated accounts, marking steady growth since March 2026. However, daily active addresses have declined to a 2026 low of 25,350, indicating less frequent user engagement despite overall adoption. XRP's price f...

Protocol Fundamentals
Neutral
4 hours ago
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