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Basilea starts first human trial of novel antibiotic BAL2420 targeting resistant gram-negative bacteria

Company Fundamentals
23 Mar 2026
Globe News Wire
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Bullish
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Basilea Pharmaceutica has initiated a Phase-1 clinical trial administering BAL2420, a new antibiotic targeting the LptA protein in gram-negative bacteria, to the first healthy volunteer. This novel drug shows strong activity against resistant strains like E. coli and K. pneumoniae, including those resistant to last-resort antibiotics. The trial aims to evaluate safety and dosing, supporting further development against serious bacterial infections. The project is partly funded by CARB-X and other global health agencies due to the urgent need for new treatments against resistant pathogens.

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