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Pevifoscorvir sodium shows promising long-term effects in reducing HBV markers, advancing chronic hepatitis B treatment.

Market News
27 May 2026
GlobeNewsWire
View Source
Bullish
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Aligos Therapeutics presented positive long-term data at the EASL Congress 2026 showing that pevifoscorvir sodium monotherapy reduces the cccDNA reservoir in chronic hepatitis B patients, potentially enabling functional cure. About 40% of treated HBeAg+ patients had significant reductions in HBsAg, making them eligible for further antisense oligonucleotide (ASO) therapy. The combination of pevifoscorvir sodium with ASO ALG-170675 showed additive to synergistic antiviral effects, suggesting pevifoscorvir sodium could replace current standard treatments and play a key role in functional cure regimens. Further clinical development and regulatory progress are anticipated.

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