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Phase 3 trial shows venetoclax combo extends progression-free survival in untreated chronic lymphocytic leukemia.

Company Fundamentals
12 Jun 2026
PRNewsWire
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Bullish
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AbbVie announced final Phase 3 results from the CLL14 trial showing that a fixed-duration venetoclax plus obinutuzumab treatment significantly improves progression-free survival (PFS) in previously untreated chronic lymphocytic leukemia (CLL) patients compared to chlorambucil plus obinutuzumab. The nine-year data revealed a median PFS of 6.4 years versus 3.2 years and a median time to next treatment of 7.6 years, highlighting durable efficacy and safety. This supports venetoclax-based regimens as a first-line treatment offering patients longer treatment-free periods. The trial enrolled 432 patients with coexisting conditions, confirming the combination's benefit in unfit patients.

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